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KMID : 0191119990140060613
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Journal of Korean Medical Science
1999 Volume.14 No. 6 p.613 ~ p.622
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Partial liquid ventilation with perfluorocarbon improves gas exchange and decreases inflammatory response in oleic acid-induced lung injury in beagles
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Suh GY
Chung MP/Park SJ/Park JW/Kim HC/Kim H/Han J/Rhee CH/Kwon OJ
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Abstract
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The aim of this study was to determine the effect of partial liquid ventilation (PLV) using a perfluorocarbon
(PFC) on gas exchange and lung inflammatory response in a canine acute lung injury model. After inducing severe
lung injury by oleic acid infusion, beagle dogs were randomized to receive either gas ventilation only (control
group, n = 6) or PLV (PLV group, n = 7) by sequential instillation of 10 mL/kg of perfluorodecalin (PFC) at 30
min intervals till functional residual capacity was attained. Measurements were made every 30 min till 210 min.
Then the lungs were removed and bronchoalveolar lavage (BAL) (35 mL/kg) was performed on the right lung and the
left lung was submitted for histologic analysis. There was significant improvement in PaO2 and PaCO2 in the PLV
group compared to the control group (p < 0.05) which was associated with a significant decrease in shunt (p < 0.05).
There was no significant difference in parameters of lung mechanics and hemodynamics. There was a significant decrease
in cell count and neutrophil percentage in BAL fluid and significantly less inflammation and exudate scores in histology
in the PLV group (p < 0.05). We conclude that PLV with perfluorodecalin improves gas exchange and decreases inflammatory
response in the acutely-injured lung.
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